Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index
Autor: | Hui Chen, Fabrice Andre, Gerasimos Anagnostopoulos, Frédéric Fumeron, Isabelle Martins, Antoine Lafarge, François Goldwasser, Franziska Grundler, Frank Madeo, Maria Castedo, Benoit Blanchet, Safae Terrisse, Ines Vaz-Luis, Adrien Joseph, Omar Motiño, Françoise Wilhelmi de Toledo, Ronan Roussel, Laurence Zitvogel, Karine Clément, Anne Laure Martin, Maria Chiara Maiuri, Léa Montégut, Guido Kroemer |
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Přispěvatelé: | HAL-SU, Gestionnaire, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Institut Gustave Roussy (IGR), Université Paris-Saclay, Service de Nutrition [CHU Pitié-Salpétrière], Institut E3M [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), UNICANCER, Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse (U981), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Direction de la recherche [Gustave Roussy], Buchinger Wilhelmi Clinic, Karl-Franzens-Universität Graz, Centre d'Investigation Clinique en Biotherapie des cancers (CIC 1428 , CBT 507 ), Institut Gustave Roussy (IGR)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), University of Chinese Academy of Sciences [Beijing] (UCAS), Karolinska University Hospital [Stockholm], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Nutrition et obésités: approches systémiques (nutriomics) (UMR-S 1269 INSERM - Sorbonne Université), Karl-Franzens-Universität [Graz, Autriche], Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Service de nutrition [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), University of Graz |
Rok vydání: | 2021 |
Předmět: |
Male
Cancer Research medicine.medical_specialty Immunology Adipose tissue Context (language use) Article Body Mass Index Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience Mice 0302 clinical medicine Overnutrition Internal medicine Germany [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine Animals Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Obesity 030304 developmental biology [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism 2. Zero hunger Diazepam Binding Inhibitor Mice Knockout 0303 health sciences QH573-671 Chemistry Binding protein Body Weight Diagnostic markers Cell Biology [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism medicine.disease 3. Good health Mice Inbred C57BL Endocrinology Female France medicine.symptom Cytology Body mass index Diazepam binding inhibitor Weight gain 030217 neurology & neurosurgery Homeostasis |
Zdroj: | Cell Death & Disease Cell Death and Disease, Vol 12, Iss 6, Pp 1-14 (2021) Cell Death and Disease Cell Death and Disease, 2021, 12 (6), pp.599. ⟨10.1038/s41419-021-03864-9⟩ Cell Death and Disease, Nature Publishing Group, 2021, 12 (6), pp.599. ⟨10.1038/s41419-021-03864-9⟩ |
ISSN: | 2041-4889 |
Popis: | In mice, the plasma concentrations of the appetite-stimulatory and autophagy-inhibitory factor acyl-coenzyme A binding protein (ACBP, also called diazepam-binding inhibitor, DBI) acutely increase in response to starvation, but also do so upon chronic overnutrition leading to obesity. Here, we show that knockout of Acbp/Dbi in adipose tissue is sufficient to prevent high-fat diet-induced weight gain in mice. We investigated ACBP/DBI plasma concentrations in several patient cohorts to discover a similar dual pattern of regulation. In relatively healthy subjects, ACBP/DBI concentrations independently correlated with body mass index (BMI) and age. The association between ACBP/DBI and BMI was lost in subjects that underwent major weight gain in the subsequent 3–9 years, as well as in advanced cancer patients. Voluntary fasting, undernutrition in the context of advanced cancer, as well as chemotherapy were associated with an increase in circulating ACBP/DBI levels. Altogether, these results support the conclusion that ACBP/DBI may play an important role in body mass homeostasis as well as in its failure. |
Databáze: | OpenAIRE |
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