Post-stress glucose consumption facilitates hormesis and resilience to severe stress
| Autor: | Michael S. Fanselow, Thomas R. Minor, Michael A Conoscenti, Traci N Plumb |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Physiology
media_common.quotation_subject macromolecular substances Article Stress (mechanics) 03 medical and health sciences Behavioral Neuroscience Hormesis 0302 clinical medicine Helplessness Learned Escape Reaction Animals Medicine Stress resilience media_common Electroshock Endocrine and Autonomic Systems business.industry musculoskeletal neural and ocular physiology Rats 030227 psychiatry Psychiatry and Mental health Glucose Neuropsychology and Physiological Psychology Oral ingestion nervous system Psychological resilience business Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Stress |
| ISSN: | 1607-8888 1025-3890 |
| DOI: | 10.1080/10253890.2021.1931677 |
| Popis: | Oral ingestion of a glucose solution following severe stress is a simple and effective way of preventing several of the negative sequelae of stress in rats. Similar resilience is obtained through hormetic training – pre-exposure to mild-to-moderate stress prior to severe stress. Here, we examined whether hormetic training is facilitated when a glucose solution is available following each hormetic training session. In Experiment 1, all rats were pre-exposed to a 30 min hormetic session of 25 inescapable tailshocks on each of 3 days. The schedule or hormesis differed between groups. The hormetic sessions occurred on either 3 consecutive days or with an interpolated day of rest between each hormetic session. Furthermore, in each of these conditions, one group had access to water and one group had access to a 40% glucose solution immediately after each hormetic session to complete a 2×2 factorial design. All groups were exposed to 100 inescapable tailshocks on the day following the end of hormetic training. Shuttle-escape testing occurred 24 h later. In Experiment 2, rats received two consecutive days of 100 inescapable tailshocks. Water or glucose was available following each session. Testing occurred 24 h after the second shock exposure. Experiment 1 replicated previous findings that rats exposed to hormetic training with interpolated rest did not show exaggerated fear responding or shuttle-escape deficits that normally result from 100 inescapable tailshocks, but training was ineffective if no rest was given between stress sessions. However, all post-stress glucose groups showed an elimination of helpless behavior. In Experiment 2, it was revealed that even 100 tailshocks can be made hormetic by post-stress glucose consumption. |
| Databáze: | OpenAIRE |
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