Oxazolomycins: natural product lead structures for novel antibacterials by click fragment conjugation
| Autor: | Mark G. Moloney, Claire L. Bagwell, Muhammad Yaqoob |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Staphylococcus aureus
Lactams Stereochemistry Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Biochemistry chemistry.chemical_compound Fragment (logic) Amide Drug Discovery Escherichia coli otorhinolaryngologic diseases Humans Spiro Compounds Molecular Biology Oxazolomycin Oxazoles Biological Products Natural product Molecular Structure Organic Chemistry Bacterial Infections Combinatorial chemistry Amides Pyrrolidinones Anti-Bacterial Agents chemistry Lactam Molecular Medicine Antibacterial activity |
| Zdroj: | Bioorganic and medicinal chemistry letters. 20(7) |
| ISSN: | 1464-3405 0960-894X |
| Popis: | Conjugation of amide and lactam subunits by a 'Click' type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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