Removal and modification of directing groups used in metal-catalyzed C–H functionalization: the magical step of conversion into ‘conventional’ functional groups

Autor:	Karunanidhi Murali, Renato L. Carvalho, Eufrânio N. da Silva Júnior, Leandro F. Pedrosa, Debabrata Maiti, Renata G. Almeida, Luana A. Machado, Pravas Dolui
Rok vydání:	2021
Předmět:	Group strategy Organic Chemistry Regioselectivity Biochemistry Combinatorial chemistry Catalysis Metal chemistry.chemical_compound chemistry visual_art Functional group visual_art.visual_art_medium Surface modification Physical and Theoretical Chemistry
Zdroj:	Organic & Biomolecular Chemistry. 19:525-547
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d0ob02232b
Popis:	Over the past few decades, regioselective catalytic C-H functionalization has provided an attractive tool for unique retrosynthetic disconnections. The advancement of the directing group strategy in metal catalyzed synthetic transformation has contributed significantly to the incorporation of a wide range of functionalization reactions in both aromatic systems and aliphatic backbones. However, the extensive utilization of these methodologies depends on the ease of removal of the directing group to restore the free functional group. In this review, we have summarised the reported approaches for removing/modifying versatile directing groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e11c64409268bcc5118aa6d6aaad327 https://doi.org/10.1039/d0ob02232b Zobrazit plný text záznamu