Respiratory mechanics before and after late artificial surfactant rescue
| Autor: | Galpérine I, M. L. Choukroun, Hervé Guénard, J.L. Demarquez, Fayon M, D.A. Todd, C. Kays |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neonatal intensive care unit Pulmonary resistance Hyaline Membrane Disease Phosphorylcholine Respiratory physiology Infant Premature Diseases Pulmonary compliance Polyethylene Glycols Pulmonary surfactant Fraction of inspired oxygen Medicine Humans Prospective Studies Prospective cohort study business.industry Age Factors Infant Newborn Pulmonary Surfactants Combined Modality Therapy Respiration Artificial Drug Combinations Anesthesia Pediatrics Perinatology and Child Health Respiratory Mechanics Female Synthetic surfactant Fatty Alcohols business |
| Zdroj: | Journal of paediatrics and child health. 31(6) |
| ISSN: | 1034-4810 |
| Popis: | Objective: To assess the effect of late administration of synthetic surfactant (Exosurf) on the ventilatory function of premature infants with hyaline membrane disease (HMD). Methodology: Prospective non-randomized study in the Neonatal Intensive Care Unit (NICU) of a major referral hospital. The patients included two groups of premature infants with a birthweight between 750 and 2000 g who developed HMD. In group 1 with moderate to severe HMD, 2x5mL/kg doses of Exosurf were given 12h apart (first dose given at a mean age of 18.7±3.4h [mean ± s.e.m.]). In group 2 with milder HMD, no surfactant was given. Results: Significant reductions (P>0.05) in the fraction of inspired oxygen (Flo2) occurred 6 h after surfactant administration (24 h of life) and by 48 h (64 h of life) in group 2. These improvements in gas exchange preceded improvements in passive respiratory compliance which occurred 24 h after surfactant (42 h of life) and by 72 h (88 h of life) in group 2 (P>0.01). In both groups pulmonary resistance increased and was significant (P>0.05) by 48 h (66 h of life) in group 1. Conclusions: Synthetic surfactant given as late as a mean age 18.7±3.4 h still improves gas exchange but these early improvements cannot be completely explained by modifications of respiratory compliance. |
| Databáze: | OpenAIRE |
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