Chronic Low Back Pain: Current Pharmacotherapeutic Therapies and a New Biological Approach
Autor: | O Sleglova, P Kostiuk, A M Meroni, L Kotlarova, M. Votavova, J Sliva, Z Prochazka, H Jarosova, R Svobodova, L Milani, K Pavelka |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Pain control Drug Discovery Humans Medicine Acute low back pain Pharmacology Analgesics business.industry Organic Chemistry Treatment method humanities Chronic low back pain Quality of Life Life expectancy Physical therapy Molecular Medicine Chronic Pain business Low Back Pain human activities 030217 neurology & neurosurgery |
Zdroj: | Current Medicinal Chemistry. 26:1019-1026 |
ISSN: | 0929-8673 |
Popis: | Chronic low back pain (CLBP) syndrome represents one of the leading causes of long-term disability worldwide. The prevalence of CLBP has been rising significantly in relation to increasing average life expectancy. CLBP results from chronification of acute low back pain. There are many factors contributing to the CLBP crisis; common etiopathogenetic factors include e.g., functional blockage of intervertebral joints. The treatment of CLBP is complex. An important part of treatment consists of pain pharmacotherapy, for which several groups of drugs are used. The problem lies in the side effects of many of these traditionally used medications. Therefore, new and safer treatment methods are being sought. Innovative options for CLBP pharmacology include injections containing collagen, which can be combined with other traditionally used drugs, which helps reduce dosages and increase the overall safety of CLBP therapy. |
Databáze: | OpenAIRE |
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