Membrane attack complex (C5b‐9 complex or Mac), is strongly present in lesional skin from patients with endemic pemphigus foliaceus in El Bagre, Colombia

Autor:	César D N Pulido, Eduardo Upegui-Quiceno, Alejandra M. Jiménez-Echavarría, Natalia-Regina Mesa-Herrera, Yulieth Alexandra Upegui-Zapata, Michael S. Howard, Ana Maria Abreu-Velez, Bruce R. Smoller, Carlos Andres Valencia-Yepes
Rok vydání:	2019
Předmět:	Male Pathology medicine.medical_specialty Histology Biopsy H&E stain Dermatology Colombia Severity of Illness Index Skin Diseases Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Humans Medicine Autoantibodies Skin business.industry Autoantibody IIf Complement System Proteins Immunohistochemistry Staining Titer Case-Control Studies 030220 oncology & carcinogenesis Endemic pemphigus foliaceus Female Complement membrane attack complex business Pemphigus
Zdroj:	Journal of Cutaneous Pathology. 46:925-929
ISSN:	1600-0560 0303-6987
DOI:	10.1111/cup.13565
Popis:	BACKGROUND El Bagre endemic pemphigus foliaceus (El Bagre-EPF) is a new variant of endemic pemphigus foliaceus present in the El Bagre area of Colombia, South America. Here, we investigate the presence of complement/C5-b9 in lesional skin of patients and matched controls from the endemic area. We also aim to compare the patient's autoantibody levels using indirect immunofluorescent titers (IIF) and correlate with the lesional presence of complement/C5b-9. METHODS A case-control study was carried out by testing for the presence of complement/C5b-9 in lesional skin in 43 patients affected by El Bagre-EPF, as well as 43 matched, healthy controls from the endemic area. Skin biopsies were obtained and evaluated via hematoxylin and eosin staining, and immunohistochemistry. RESULTS The presence of complement/C5b-9 was observed in all cases of the patients affected by El Bagre-EPF and was not observed in the controls from the endemic area (P
Databáze:	OpenAIRE
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