| Popis: |
Candida bloodstream infections (BSI) have become a major healthcare problem, specially in tertiarycare hospitals worldwide (Al-Jasser & Elkhizzi, 2004, Almirante et al., 2005, AlonsoValle et al., 2003, Atunes et al., 2004 Asmundsdottir et al., 2002, Costa et al., 2000, Fraser et al., 1992, Garbino et al., 2002, Luzzati et al. 2000, Marchetti et al., 2004, Pappas et al., 2003, Viudes et al., 2002). Several risk factor identified among patients hospitalized for long periods such as the exposition to broad spectrum antimicrobial and/or immunosuppressive chemotherapy, parenteral nutrition, and invasive medical procedures have contributed to this fact (Blumberg et al., 2001, Fraser et al., 1992). Despite some improvements in fungal BSI diagnosis during last years, candidemia diagnosis remains difficult. Besides, following the data appeared in the classical study from Berenguer and colleagues, only 50% of patients with disseminated candidiasis will have positive blood cultures and even fewer will have an antemortem diagnosis (15% to 40%) (Berenguer et al., 1993). Therefore, invasive candidemia is not easy to diagnose, has an expensive treatment and finally is a serious, often lifethreatening infection (Girmenia et al., 1996, Messer et al., 2009). |
