Thyroid Peroxidase Immunohistochemistry in Differential Diagnosis of Thyroid Tumors
| Autor: | Ivan Paunovic, Ivana Petrović, Tijana Isic, Havelka M, Svetislav Tatic, Svetlana Savin, Dubravka Cvejic |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adenoma
endocrine system Pathology medicine.medical_specialty Endocrinology Diabetes and Metabolism Iodide Peroxidase Sensitivity and Specificity Pathology and Forensic Medicine Diagnosis Differential Immunoenzyme Techniques Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Endocrinology Thyroid peroxidase Biomarkers Tumor Medicine Thyroid Neoplasms Thyroid cancer Retrospective Studies 030304 developmental biology Tumor marker 0303 health sciences biology business.industry Carcinoma Thyroid food and beverages Cancer General Medicine medicine.disease Thyroid Diseases 3. Good health medicine.anatomical_structure 030220 oncology & carcinogenesis embryonic structures biology.protein Immunohistochemistry business Immunostaining |
| Zdroj: | Endocrine Pathology. 17:53-60 |
| ISSN: | 1046-3976 |
| DOI: | 10.1385/ep:17:1:53 |
| Popis: | Thyroperoxidase (TPO) is a thyroid-specific enzyme expressed by differentiated thyroid cells. Initial immunohistochemical studies claimed that TPO expression, detected by the monoclonal antibody mAb 47, may be a potentially important diagnostic tool in differentiating malignant from benign lesions. However, some recent studies have failed to reproduce the earlier results, suggesting the limitations for TPO immunohistochemistry. To assess these observations we have evaluated the immunohistochemical expression of TPO in thyroid tissue from 215 patients. The studied material included 87 nonmalignant thyroid lesions and 128 thyroid carcinomas. TPO expression was investigated using newly available mAb 47 and staining of less than 80% of the follicular cells/specimen as the threshold indicating a malignant lesion. We found that TPO had a sensitivity of 89.9% for cancer and a specificity of 64.4% for nonmalignant lesions, showing that it does not give a sufficient degree of diagnostic certainty that the lesion is benign. In addition, the variability in the degree of TPO expression found within and between follicular carcinomas, and the significant number of benign adenomas having similar immunostaining patterns, assured us that TPO immunostaining is not sufficiently discriminatory in the differential diagnosis of thyroid cancer versus benign lesions. |
| Databáze: | OpenAIRE |
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