Remembering Statins: Do Statins Have Adverse Cognitive Effects?
| Autor: | Rafael Bitzur |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions Endocrinology Diabetes and Metabolism Alternative medicine MEDLINE Disease 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Cognition Randomized controlled trial law Health care Internal Medicine medicine Humans Prospective Studies Cognitive decline Intensive care medicine Advanced and Specialized Nursing business.industry United States Food and Drug Administration United States Cardiovascular Diseases Mental Recall Observational study Hydroxymethylglutaryl-CoA Reductase Inhibitors business Cognition Disorders 030217 neurology & neurosurgery |
| Zdroj: | Diabetes care. 39 |
| ISSN: | 1935-5548 |
| Popis: | The issue of statin-associated cognitive impairment has been a hot topic among both patients and health care providers, especially since the U.S. Food and Drug Administration (FDA) issued a statement regarding rare postmarketing reports of ill-defined cognitive impairment associated with statin use. This statement was based on case reports, and no objective measures of cognitive function were used. Nevertheless, many patients at high risk of cardiovascular disease have expressed concerns about possible cognitive decline and may have opted to forgo statin therapy. In this overview, the evidence leading to the statement by the FDA is reviewed. Potential mechanisms of the effect of LDL cholesterol reduction and statin therapy on cognition are discussed. Evidence from observational and prospective randomized trials is summarized, leading to the conclusion that as for now, there is no good evidence that statins cause cognitive impairment to a significant degree. Reported cases seem to be rare, and a causal relationship has not been established. |
| Databáze: | OpenAIRE |
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