Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study
| Autor: | Naomi I. Eisenberger, Jennifer L. Kruse, Richard G. Olmstead, Joshua Hyong-Jin Cho, Lin Hwang, Michael R. Irwin, Kym F. Faull |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Kynurenine pathway Endocrinology Diabetes and Metabolism Metabolite medicine.medical_treatment Profile of mood states Kynurenic Acid Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Kynurenic acid Sex Factors Internal medicine medicine Humans Biological Psychiatry Kynurenine Inflammation Endocrine and Autonomic Systems business.industry Depression Interleukin-6 Tumor Necrosis Factor-alpha Tryptophan Middle Aged Quinolinic Acid 030227 psychiatry Endotoxins Psychiatry and Mental health Affect Cytokine chemistry Cytokines Tumor necrosis factor alpha Female business 030217 neurology & neurosurgery Quinolinic acid |
| Zdroj: | Psychoneuroendocrinology |
| ISSN: | 1873-3360 |
| Popis: | Inflammation has an important physiological influence on mood and behavior. Kynurenine metabolism is hypothesized to be a pathway linking inflammation and depressed mood, in part through the impact of kynurenine metabolites on glutamate neurotransmission in the central nervous system. This study evaluated whether the circulating concentrations of kynurenine and related compounds change acutely in response to an inflammatory challenge (endotoxin administration) in a human model of inflammation-induced depressed mood, and whether such metabolite changes relate to mood change. Adults (n = 115) were randomized to receive endotoxin or placebo. Mood (Profile of Mood States), plasma cytokine (interleukin-6, tumor necrosis factor-α) and metabolite (kynurenine, tryptophan, kynurenic acid, quinolinic acid) concentrations were repeatedly measured before the intervention, and at 2 and 6 h post-intervention. Linear mixed models were used to evaluate relationships between mood, kynurenine and related compounds, and cytokines. Kynurenine, kynurenic acid, and tryptophan (but not quinolinic acid) concentrations changed acutely (p's all |
| Databáze: | OpenAIRE |
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