The Anticonvulsant Effects of Alpha-2 Adrenoceptor Agonist Dexmedetomidine on Pentylenetetrazole-Induced Seizures in Rats
Autor: | Handan Gunes, Erkan Gumus, Gokhan Arslan, Ahmet Sevki Taskiran, Arzuhan Cetindag Ciltas, Ercan Ozdemir |
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Rok vydání: | 2021 |
Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class medicine.medical_treatment Hippocampal formation Biochemistry Cellular and Molecular Neuroscience Epilepsy Seizures Internal medicine medicine Animals Rats Wistar business.industry Dentate gyrus Antagonist Atipamezole General Medicine medicine.disease Rats Receptors Adrenergic Endocrinology Anticonvulsant Pentylenetetrazole Anticonvulsants Alpha-2 adrenergic receptor business Dexmedetomidine medicine.drug |
Zdroj: | Neurochemical Research. 47:305-314 |
ISSN: | 1573-6903 0364-3190 |
Popis: | Alpha2-adrenoreceptor (α2-AR) is a noradrenergic receptor that is frequently studied for modulation of seizure activity. However, the precise role of this receptor agonists in regulating seizure activity is still unclear. Our aim in this study was to investigate the effects of α2-AR agonist dexmedetomidine (DEX) and atipamezole (α2-AR antagonist, ATI) on seziures in rats. In the study, 32 adult male Wistar Albino rats (weighing 220–260 g) were used. To induce seizures in rats, pentylenetetrazole (PTZ, 35 mg/kg) was injected intraperitoneally (i.p.) and seizure stages were determined according to the Racine scale. After induction of seizures, DEX (0.1 mg/kg, i.p.) and ATI (1 mg/kg, i.p.) were administered to rats and their effects determined on seizures. GABA levels of the brain hippocampal tissue sample were measured using an ELISA kit and c-Fos positive cells of the dentate gyrus and hippocampal regions were quantitatively analyzed with Image J software. The results showed that DEX decreased the seizure stages according to the Racine scale, significantly prolonged the onset time of first myoclonic jerk (FMJ) and reduced the number of spikes and percentage seizure duration (p |
Databáze: | OpenAIRE |
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