The influence of testosterone suppression on HER2 immunoexpression in prostatic neoplastic tissue
| Autor: | Marcos Tobias-Machado, Marcelo Langer Wroclawski, Marília Germanos de Castro, Nicolle Martin Christofe, Thiago Fernandes Negris Lima, Sidney Glina, Lucila Heloisa Simardi Santiago, Fernando Korkes, Guilherme Andrade Peixoto, Cristiano Linck Pazeto |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment Perineural invasion Androgen deprivation therapy chemistry.chemical_compound Prostate cancer HER2 Internal medicine medicine prostate-specific antigen Gleason score Prostatectomy business.industry biomarkers Cancer Cyproterone acetate Articles prostate cancer medicine.disease Prostate-specific antigen chemistry immunohistochemistry T-stage business |
| Zdroj: | Molecular and Clinical Oncology |
| ISSN: | 2049-9469 2049-9450 |
| DOI: | 10.3892/mco.2021.2347 |
| Popis: | During initial risk assessments, the metastatic potential of prostate cancer (PCa) may not be fully considered. The tumor's multicentric origin, which is associated with genetic mutations, may explain existing treatment limitations. Investigating human epidermal growth factor receptor 2 (HER2) expression in patients with different stages of PCa may therefore increase understanding of the mechanisms associated with the development of castration resistance. The present study examined the association between HER2 expression and the histologic features of PCa subjected to radical prostatectomy (RP) and evaluated the role of testosterone suppression in HER2 expression. In group 1, specimens from individuals who underwent RP without prior neoadjuvant androgen deprivation therapy (ADT) were included (n=42). In group 2 (PCa with ADT), specimens from individuals who underwent RP and received neoadjuvant cyproterone acetate during distinct periods (200 mg daily for 1-24 months) were included (n=150; cohort derived from a previous study). Immunohistochemical expression of HER2 was associated with prognostic factors such as perineural invasion, extra-prostatic disease, T stage, serum prostate-specific antigen (PSA), angiolymphatic invasion and surgical margins. Univariate regression analysis indicated that perineural invasion, PSA, International Society of Urological Pathology, angiolymphatic invasion, margin, T stage and neoadjuvant ADT was associated with HER2 expression. Ordinal regression analysis indicated a significant effect of neoadjuvant ADT alone on HER2 expression (P |
| Databáze: | OpenAIRE |
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