Are we giving up on adequate statin doses too easily?
| Autor: | Jasna Čerkez Habek |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
statini pleiotropni učinak prevencija kardiovaskularnih bolesti miopatije Statin business.industry medicine.drug_class medicine Cardiology and Cardiovascular Medicine Intensive care medicine business statins pleiotropic effect prevention of cardiovascular diseases myopathies |
| Zdroj: | Cardiologia Croatica Volume 11 Issue 7 |
| ISSN: | 1848-5448 1848-543X |
| DOI: | 10.15836/ccar2016.296 |
| Popis: | Koronarna bolest srca vodeći je uzrok mortaliteta u razvijenim zemljama, a hiperkolesterolemija jedan je od značajnih čimbenika rizika za razvoj ateroskleroze. U nastojanjima reduciranja učestalosti neželjenih kardiovaskularnih događaja, nužnost je efikasno sniziti koncentraciju serumskog LDL kolesterola, posebice stoga što je to čimbenik rizika koji, uz terapiju, možemo znatno modificirati. Statini su temeljni lijekovi za primarnu i sekundarnu prevenciju kardiovaskularnih bolesti, a njihovo djelovanje dovodi do sniženja ukupnog i LDL kolesterola u plazmi, ali usporivanju procesa ateroskleroze i stabilizaciji ateroma pridonose i brojni drugi učinci statina, povrh samo sniženja razine kolesterola. Upravo iz metaboličkog učinka statina razjašnjena je i moguća etiologija miopatije koja se pojavljuje kao relativna česta pritužba bolesnika, zbog čega se smanjuje doza lijeka ili prekida liječenje, čime se bolesnik izlaže ponovno povišenom riziku za razvoj neželjenoga kardiovaskularnog događaja. Stoga su ovdje navedene i dosadašnje spoznaje o etiologiji i liječenju spomenute nuspojave. Coronary heart disease is the leading cause of mortality in developed countries, and hypercholesterolemia is one of the significant risk factors for the development of atherosclerosis. Attempts to reduce the incidence of cardiovascular events necessitate efficient lowering of LDL cholesterol concentrations, especially since this is a risk factor that we can significantly modify through treatment. Statins are basic drugs for the primary and secondary prevention of cardiovascular diseases, and their activity leads to a reduction in plasma levels of total and LDL cholesterol, but other numerous effects of statins beyond just the reduction of cholesterol levels contribute to atheroma stabilization and slowing down the process of atherosclerosis. It is the metabolic effect of statins that explains the possible etiology of myopathy, which is a relatively common patient complaint leading to reduction in dosage or treatment termination, which once again exposes the patient to increased risk of the development of unwanted cardiovascular events. Thus, the current knowledge on the etiology and treatment of this side effect is also addressed in this article. |
| Databáze: | OpenAIRE |
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