Pediocin-like bacteriocins: new perspectives on mechanism of action and immunity
| Autor: | Augusto Bellomio, Natalia Soledad Ríos Colombo, Silvia Adriana Navarro, Miriam Carolina Chalon |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pediocins Otras Ciencias Biológicas 030106 microbiology Antimicrobial peptides Mannose Biology MAN-PTS Microbiology Ciencias Biológicas 03 medical and health sciences chemistry.chemical_compound MECHANISM OF ACTION Bacteriocins Bacteriocin Immunity Food Preservation Genetics medicine Humans BACTERIOCIN General Medicine PEP group translocation Models Theoretical biochemical phenomena metabolism and nutrition Transmembrane protein Anti-Bacterial Agents 030104 developmental biology Biochemistry Mechanism of action chemistry bacteria MEMBRANE medicine.symptom Peptides IMMUNITY PROTEIN CIENCIAS NATURALES Y EXACTAS Function (biology) |
| Zdroj: | Current Genetics. 64:345-351 |
| ISSN: | 1432-0983 0172-8083 |
| DOI: | 10.1007/s00294-017-0757-9 |
| Popis: | This review attempts to analyze the mechanism of action and immunity of class IIa bacteriocins. These peptides are promising alternative food preservatives and they have a great potential application in medical sciences. Class IIa bacteriocins act on the cytoplasmic membrane of Gram-positive cells dissipating the transmembrane electrical potential by forming pores. However, their toxicity and immunity mechanism remains elusive. Here we discuss the role of the mannose phosphotransferase system (man-PTS) as the receptor for class IIa bacteriocins and the influence of the membrane composition on the activity of these antimicrobial peptides. A model that is consistent with experimental results obtained by different researchers involves the non-specific binding of the bacteriocin to the negatively charged membrane of target bacteria. This step would facilitate a specific binding to the receptor protein, altering its functionality and forming an independent pore in which the bacteriocin is inserted in the membrane. An immunity protein could specifically recognize and block the pore. Bacteriocins function in bacterial ecosystems and energetic costs associated with their production are also discussed. Theoretical models based on solid experimental evidence are vital to understand bacteriocins mechanism of action and to promote new technological developments. Fil: Ríos Colombo, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Chalon, Miriam Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Navarro, Silvia Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Bellomio, Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina |
| Databáze: | OpenAIRE |
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