Increased release of xylocholine (TM10) from guinea-pig vas deferens treated with amphetamine sulphate
| Autor: | H. G. Dean, I. E. Hughes |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Guinea Pigs Iodide Pharmaceutical Science Adrenergic Stimulation In Vitro Techniques Xylenes Choline Guinea pig chemistry.chemical_compound Vas Deferens Internal medicine medicine Animals Amphetamine Incubation Pharmacology chemistry.chemical_classification Carbon Isotopes Chemistry Vas deferens Electric Stimulation medicine.anatomical_structure Endocrinology medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 24:183-188 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1972.tb08962.x |
| Popis: | Although both NN-diethyl- and NN-dimethyl-, N-methyl-[14C]-2-(2,6-xylyloxy) ethylammonium iodide (14C-1DE10 iodide and 14C-TM10 iodide; xylocholine) are taken up by guinea-pig vas deferens to a similar extent in vitro, only TM10 reduced the response of the vas deferens to electrical stimulation. Prior incubation of vas deferens with 14C-1DE10 iodide or with 14C-TM10 iodide followed by measurement of the amount of each of these compounds eliminated from the tissue by repeated washing with Krebs solution, shows both compounds to be strongly retained by the tissue. Incorporation of 10−5 g/ml amphetamine sulphate in the wash fluid failed to modify the release of 14C-1DE10 iodide but produced a short-lived increase in the amount of 14C-TM10 iodide eliminated which reached a maximum approximately 10 min after administration of amphetamine. The additional 14C-TM10 iodide eliminated by amphetamine was about 5% of the total tissue 14C-TM10 iodide content; the possible role of this fraction is discussed in relation to the adrenergic neuronblocking action of 14C-TM10 iodide. |
| Databáze: | OpenAIRE |
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