Myocardial oxidative stress and antioxidants in hypertension as a result of nitric oxide synthase inhibition
| Autor: | Antonio Andrea Bello, Travacio M, Adriane Belló-Klein, Patricia Martins Bock, Sueli M. Senna, de Bittencourt Pi, Pawan K. Singal, S. Llesuy, Kumar D, Maria Claudia Irigoyen |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Glutamate-Cysteine Ligase Toxicology medicine.disease_cause Plasma renin activity Nitroarginine Antioxidants Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Internal medicine Renin medicine Animals Enzyme Inhibitors Rats Wistar Molecular Biology chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Glutathione peroxidase Myocardium Heart Catalase Glutathione Rats Nitric oxide synthase Oxidative Stress Endocrinology Blood pressure Glutathione Reductase chemistry Hypertension biology.protein Nitric Oxide Synthase Cardiology and Cardiovascular Medicine Oxidative stress |
| Zdroj: | Cardiovascular toxicology. 1(1) |
| ISSN: | 1530-7905 |
| Popis: | Rats were made hypertensive by the administration of the nitric oxide synthase inhibitor nitro-L-arginine (LNA, 2.74 mmol/L) in drinking water for 7 d. Hearts from hemodynamically assessed animals were analyzed for lipid peroxidation (LPO), gamma-glutamylcysteine-synthetase (gamma-GCS), glutathione disulfide reductase (GR), glutathione peroxidase (GSHPx), catalase (CAT), superoxide dismutase (SOD), and total radical trapping potential (TRAP) activities. LNA treatment increased the mean arterial blood pressure by 46% and the heart rate by 22% without changing plasma renin activity. LNA treatment resulted in a 30% increase in LPO. gamma-GCS was reduced by 48% and GR by 36% in the cardiac tissue of hypertensive rats as compared to controls. The activity of nonselenium GSHPx was reduced by 27%, and selenium-dependent GSHPx activity in the heart was not affected by LNA treatment. In hypertensive rats, SOD activity was increased by 16%, and CAT was decreased by 46%. TRAP was lower (27%) in the myocardium of hypertensive rats than in that of controls. These data suggest that LNA-induced hypertension is associated with increased myocardial oxidative stress. |
| Databáze: | OpenAIRE |
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