Associations between Health Effects and Particulate Matter and Black Carbon in Subjects with Respiratory Disease
Autor: | Jane Q. Koenig, Therese F. Mar, Timothy V. Larson, Morton Lippmann, James A. Stewart, Carrie Fields, Karen Jansen |
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Jazyk: | angličtina |
Rok vydání: | 2005 |
Předmět: |
Spirometry
Male Washington medicine.medical_specialty Health Toxicology and Mutagenesis Blood Pressure black carbon Nitric Oxide chronic obstructive pulmonary disease Animal science Heart Rate Heart rate medicine Humans panel study Lung Diseases Obstructive Particle Size Oxygen saturation (medicine) Asthma Aged particulate matter Aged 80 and over COPD Air Pollutants medicine.diagnostic_test business.industry Research Public Health Environmental and Occupational Health Age Factors Temperature Humidity asthma Middle Aged medicine.disease Confidence interval Carbon Surgery respiratory tract diseases Oxygen fractional exhaled nitric oxide Blood pressure Exhaled nitric oxide Linear Models Female business |
Zdroj: | Environmental Health Perspectives |
ISSN: | 1552-9924 0091-6765 |
Popis: | We measured fractional exhaled nitric oxide (FE(NO)), spirometry, blood pressure, oxygen saturation of the blood (SaO2), and pulse rate in 16 older subjects with asthma or chronic obstructive pulmonary disease (COPD) in Seattle, Washington. Data were collected daily for 12 days. We simultaneously collected PM10 and PM2.5 (particulate matter < or = 10 microm or < or = 2.5 microm, respectively) filter samples at a central outdoor site, as well as outside and inside the subjects' homes. Personal PM10 filter samples were also collected. All filters were analyzed for mass and light absorbance. We analyzed within-subject associations between health outcomes and air pollution metrics using a linear mixed-effects model with random intercept, controlling for age, ambient relative humidity, and ambient temperature. For the 7 subjects with asthma, a 10 microg/m3 increase in 24-hr average outdoor PM10 and PM2.5 was associated with a 5.9 [95% confidence interval (CI), 2.9-8.9] and 4.2 ppb (95% CI, 1.3-7.1) increase in FE(NO), respectively. A 1 microg/m3 increase in outdoor, indoor, and personal black carbon (BC) was associated with increases in FE(NO) of 2.3 ppb (95% CI, 1.1-3.6), 4.0 ppb (95% CI, 2.0-5.9), and 1.2 ppb (95% CI, 0.2-2.2), respectively. No significant association was found between PM or BC measures and changes in spirometry, blood pressure, pulse rate, or SaO2 in these subjects. Results from this study indicate that FE(NO) may be a more sensitive marker of PM exposure than traditional health outcomes and that particle-associated BC is useful for examining associations between primary combustion constituents of PM and health outcomes. |
Databáze: | OpenAIRE |
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