Follicular thyroid cells of autoimmune thyroiditis may coexpress ICAM-1 (CD54) and its natural ligand LFA-1 (CD11a/CD18)
| Autor: | Corrado Betterle, F. Paolieri, A. Caretto, C. Pronzato, Giorgio Walter Canonica, Carla Giordano, Giampaola Pesce, Barbara Villaggio, Marcello Bagnasco |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
endocrine system Pathology medicine.medical_specialty Goiter endocrine system diseases Graves' disease Immunology Thyroid Gland chemical and pharmacologic phenomena Epithelium Thyroiditis Autoimmune thyroiditis Thyroid peroxidase hemic and lymphatic diseases medicine Humans Immunology and Allergy Thyroid Epithelial Cells biology business.industry Thyroid Thyroiditis Autoimmune Epithelial Cells hemic and immune systems Middle Aged Intercellular Adhesion Molecule-1 medicine.disease Immunohistochemistry Graves Disease Lymphocyte Function-Associated Antigen-1 Anti-thyroid autoantibodies medicine.anatomical_structure biology.protein Female business |
| Zdroj: | Journal of Allergy and Clinical Immunology. 95:1036-1043 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/s0091-6749(95)70105-2 |
| Popis: | The leukocyte functional associated antigen-1 (LFA-1)-intercellular adhesion molecule-1 (CD11a-CD18/CD54) intercellular adhesion system plays a crucial role in several immunologic phenomena, including adhesion between lymphocytes and epithelial cells. In previous studies evidence for CD54 expression on thyroid follicular cells in Hashimoto's thyroiditis was provided. In this study we evaluated the possible expression of CD11a and CD18 antigens on thyrocytes of patients with Hashimoto's thyroiditis and on thyrocytes of patients with Graves' disease and simple goiter as controls; we used both alkaline phosphatase immunostaining and indirect immunofluorescence on cryostatic tissue sections. The results showed that LFA-1 (both CD11a and CD18) positivity on thyroid follicles may occur in glands of patients with Hashimoto's disease, with a pattern very similar to that of CD54: this was observed in five of seven specimens. Conversely, no positivity was observed in tissues from patients with Graves' disease or goiter: notably, isolated follicular cells from Graves' goiter tissues are induced in culture to express CD54, but not LFA-1. Using double-staining techniques, we were able to show that in specimens from patients with Hashimoto's disease, the same follicular structures coexpressed LFA-1 and CD54. Such a coexpression of the two ligands further emphasizes the possible role of this adhesion system in the pathogenesis of epithelial damage, through bidirectional interactions between thyroid epithelial cells and infiltrating LFA-1 or CD54-positive mononuclear cells. |
| Databáze: | OpenAIRE |
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