Adjuvant chemoradiation for high‐grade cardiac leiomyosarcoma in a child: Case report and review of literature
| Autor: | Vivi Nguyen, Thomas A. Olson, Kirk R. Kanter, Bree R. Eaton, S. Flampouri, James Janopaul-Naylor |
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| Rok vydání: | 2021 |
| Předmět: |
Leiomyosarcoma
Cardiac function curve medicine.medical_specialty Adolescent medicine.medical_treatment Heart Neoplasms Antineoplastic Combined Chemotherapy Protocols medicine Palpitations Humans Ifosfamide Cardiac Leiomyosarcoma Child business.industry Soft tissue sarcoma Chemoradiotherapy Adjuvant Hematology medicine.disease Radiation therapy Oncology Doxorubicin Pediatrics Perinatology and Child Health Female Radiology medicine.symptom business Esophagitis medicine.drug |
| Zdroj: | Pediatric Blood & Cancer. 68 |
| ISSN: | 1545-5017 1545-5009 |
| Popis: | A 13-year-old healthy girl presented with dizziness and palpitations, found to have a left atrial mass. An 8-cm tumor was removed en bloc. Pathology confirmed grade 3 leiomyosarcoma with multifocal positive margins. She received adjuvant ifosfamide and doxorubicin, followed by concurrent proton radiotherapy and ifosfamide. Radiotherapy included 66 Gy (RBE) in 33 fractions to the operative bed. Prospectively graded toxicities included Grade 2 esophagitis and Grade 1 anorexia, dermatitis, and fatigue. She completed six cycles of ifosfamide. Two years post operation, she had no evidence of disease, intermittent palpitations with normal cardiac function, and no other cardiopulmonary or esophageal symptoms. |
| Databáze: | OpenAIRE |
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