Apoliprotein E genotype is associated with apoliprotein B plasma levels but not with coronary calcium score in very elderly individuals in primary care setting
| Autor: | Wilcelly Machado-Silva, Adriane Dallanora Henriques, Simone N. Santos, Andrei C. Sposito, Luiz A. Quaglia, Otávio de Toledo Nóbrega, Cláudio Córdova, Wladimir M. Freitas, Audrey C Tonet-Furioso |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Genotype Apolipoprotein B Primary care Biology Polymerase Chain Reaction Apolipoproteins E Gene Frequency Risk Factors Internal medicine Epidemiology Genetics medicine Humans Prospective Studies Allele Aged 80 and over Primary Health Care Age Factors DNA General Medicine Atherosclerosis Prognosis Coronary Vessels Coronary Calcium Score Cross-Sectional Studies Endocrinology biology.protein Calcium Female lipids (amino acids peptides and proteins) Biomarkers Brazil Follow-Up Studies Lipoprotein |
| Zdroj: | Gene. 539:275-278 |
| ISSN: | 0378-1119 |
| Popis: | Background Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. Aim We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. Methods We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across e2, e3 and e4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events. Results When non-e4 carriers were compared with e4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups. Conclusion The study suggests a possible atherogenic role of the e4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting. |
| Databáze: | OpenAIRE |
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