Endothelial Cell Participation in Inflammatory Reaction

Autor: Marie-Paule Wautier, Jean-Luc Wautier
Rok vydání: 2021
Předmět:
0301 basic medicine
Endothelium
Inflammasomes
QH301-705.5
Angiogenesis
Receptor for Advanced Glycation End Products
Neovascularization
Physiologic
Inflammation
Review
030204 cardiovascular system & hematology
Nitric Oxide
Catalysis
RAGE (receptor)
Inorganic Chemistry
angiogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
inflammasome
Interferon
medicine
Humans
Biology (General)
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
thrombosis
Spectroscopy
SARS-CoV-2
business.industry
Organic Chemistry
Membrane Proteins
Inflammasome
General Medicine
Atherosclerosis
endothelial cells
Computer Science Applications
Endothelial stem cell
Chemistry
030104 developmental biology
medicine.anatomical_structure
chemistry
inflammation
Immunology
Advanced glycation end-product
Endothelium
Vascular
medicine.symptom
business
medicine.drug
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 6341, p 6341 (2021)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Inflammation is an old concept that has started to be considered as an important factor in infection and chronic diseases. The role of leukocytes, the plasmatic components, then of the mediators such as prostaglandins, cytokines, and, in recent decades, of the endothelium has completed the concept of the inflammation process. The function of the endothelium appeared to be crucial as a regulator or the initiator of the inflammatory process. Culture of human endothelial cells and experimental systems made it possible to define the molecular basis of inflammation in vascular diseases, in diabetes mellitus, atherosclerosis, vasculitis and thromboembolic complications. Advanced glycation end product receptor (RAGE), present on endothelial cells (ECs) and monocytes, participates in the activation of these cells in inflammatory conditions. Inflammasome is a cytosolic multiprotein that controls the response to diverse microorganisms. It is positively regulated by stimulator of interferon response CGAMP interactor-1 (STING1). Angiogenesis and thrombotic events are dysregulated during inflammation. ECs appear to be a protector, but also a possible initiator of thrombosis.
Databáze: OpenAIRE
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