Social support favors extinction and impairs acquisition of both short- and long-term contextual fear conditioning memory
| Autor: | Carolina G. Zinn, Scheila Daiane Schmidt, Flávia Fagundes Ferreira, Jociane de Carvalho Myskiw, Ivan Izquierdo, Lorena Evelyn Silva Cavalcante, Fernanda da Silva Rodrigues, Clarissa Penha Farias, Cristiane Regina Guerino Furini |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Memory Long-Term Contextual fear Extinction Psychological 03 medical and health sciences Social support 0302 clinical medicine Animals Rats Wistar Memory test Behavior Animal General Neuroscience Conditioned response Social Support Fear Extinction (psychology) Memory retention Rats Memory Short-Term 030104 developmental biology Extinction memory Conditioning Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 712:134505 |
| ISSN: | 0304-3940 |
| Popis: | Fear memory has an essential role on animal's survival once it induces defensive behavior in response to threats. Among other factors, social support is known to down-regulate the expression of fear conditioned response, representing an important modulator of fear memories. Here we studied the effects of social support during acquisition, retrieval and extinction of contextual fear conditioning (CFC) memory in rats, by exposing the animals to the CFC task either in the absence or in the presence of a conspecific during the training, extinction and/or test sessions. The presence of a conspecific during the training session of CFC resulted in impairment to memory retention as verified in the short- and long-term memory test, suggesting that social support exerts a suppressive effect on the acquisition of CFC. On retrieval, social support decreased the expression of the conditioned fear response - as also seen in the extinction session. Nevertheless, the animals were able to learn the extinction memory as verified in the retention test. Therefore, this study demonstrates the effects of social support at crucial moments in CFC: impairing memory acquisition and favoring its extinction, by reducing the expression of the conditioned fear response with no impairment to the extinction learning. |
| Databáze: | OpenAIRE |
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