Macrophages in Skin Cancer: Quantitative and Functional Studies
| Autor: | L. Bonomo, Mario Lospalluti, Antonio Miglietta, C. L. Meneghini, Franco Dammacco |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Cancer Research Skin Neoplasms Phagocytosis Cell Cell Count 030218 nuclear medicine & medical imaging Macrophage chemotaxis 03 medical and health sciences 0302 clinical medicine medicine Humans Macrophage Basal cell carcinoma Cells Cultured Aged Skin Chemistry Chemotaxis Macrophages General Medicine Middle Aged medicine.disease Trypsin In vitro medicine.anatomical_structure Oncology Carcinoma Basal Cell 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Female Neoplasm Recurrence Local Skin cancer medicine.drug |
| Zdroj: | Tumori Journal. 65:309-316 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089167906500305 |
| Popis: | The number of tumor-infiltrating macrophages was estimated in 43 patients with skin cancer, including 18 cases of squamous cell and 25 cases of basal cell carcinoma. Macrophages were identified in cell cultures by 2 assays, namely phagocytosis and resistance to detachment by trypsin. The average percentage of adherent cells for the 2 groups of skin tumors was 4.5 ± 2.6 and 10.2 ± 5.2, respectively, and the difference was statistically significant. Follow-up studies after surgical excision of the primary neoplasm showed a relatively low macrophage content in 2 of the 4 cases in which local recurrences occurred. Preliminary functional studies suggested that soluble factors may be released by neoplastic cells, accounting for the inhibitory effect of tumor cell supernatants on macrophage Chemotaxis in vitro. |
| Databáze: | OpenAIRE |
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