Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance
| Autor: | Dasja Pajkrt, Gerrit Koen, Lieke Brouwer, Hetty van Eijk, Katja C. Wolthers, Karlijn van der Straten, Jean Luc Murk, Karen Couderé |
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| Přispěvatelé: | Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), Medical Microbiology and Infection Prevention |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Genotype Enterovirus 030106 microbiology Population Parechovirus Antibodies Viral medicine.disease_cause Microbiology Article Neutralization Virus 03 medical and health sciences Seroepidemiologic Studies Virology Humans Medicine sero-surveillance education Genotyping education.field_of_study biology business.industry Immunoglobulins Intravenous virus neutralisation assay virus diseases biology.organism_classification Antibodies Neutralizing QR1-502 030104 developmental biology Infectious Diseases Population Surveillance surveillance biology.protein Public Health Antibody business |
| Zdroj: | Viruses Volume 13 Issue 6 Viruses, Vol 13, Iss 1028, p 1028 (2021) Viruses, 13(6):1028. Multidisciplinary Digital Publishing Institute (MDPI) |
| ISSN: | 1999-4915 |
| Popis: | Non-polio enteroviruses (NPEV) and parechoviruses (PeV) are widespread pathogens that cause significant morbidity. Surveillance is based on culturing or genotyping of virus strains found in clinical samples. Sero-surveillance, by measuring neutralising antibodies (nAb) through virus neutralisation assays (VNA), could provide additional information as it offers a more comprehensive overview of exposure to circulating types in the general population. In our study we evaluated Intravenous immunoglobulins (IVIG) to generate sero-surveillance data. We performed VNA of nineteen NPEV and PeV with Dutch IVIG batches from two different time points (2010 and 2017) and an IVIG batch from Vietnam (2011). We compared our findings with geno- and sero-surveillance data and evaluated changes over time and between the two countries. Our findings show a good correlation with what is known from geno-surveillance data. The highest nAb titres were found against strains from Enterovirus B, while we did not observe nAb titres against strains belonging to Enterovirus C. In conclusion, we demonstrated that sero-surveillance by means of IVIG can be used to obtain insight into circulation of EV and PeV genotypes. This is of particular interest for public health, to evaluate changes over time and population susceptibility to emerging genotypes. |
| Databáze: | OpenAIRE |
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