Leishmaniasis due to Leishmania infantum : Integration of human, animal and environmental data through a One Health approach
| Autor: | Victoriano Corpas-López, Gemma Merino-Espinosa, C. Acedo-Sanchez, Francisco Morillas-Márquez, Joaquina Martín-Sánchez, Antonio Sampedro, Javier Rodríguez-Granger, Laura Porcel-Rodríguez, José Aneiros-Fernández, Victoriano Díaz-Sáez, Luis Aliaga, Jesús Tercedor-Sánchez |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Disease Polymerase Chain Reaction 0403 veterinary science 03 medical and health sciences Dogs Epidemiology medicine Canine leishmaniasis Animals Humans Dog Diseases One Health Prospective Studies Leishmania infantum Asymptomatic Infections Leishmaniasis Retrospective Studies 030304 developmental biology 0303 health sciences General Veterinary General Immunology and Microbiology biology Incidence Incidence (epidemiology) 04 agricultural and veterinary sciences General Medicine medicine.disease biology.organism_classification Insect Vectors Spain Phlebotomus Vector (epidemiology) Immunology Leishmaniasis Visceral Female |
| Zdroj: | Transboundary and Emerging Diseases. 67:2423-2434 |
| ISSN: | 1865-1682 1865-1674 |
| Popis: | The aim of this study was to explore Leishmania infantum epidemiology through a One Health approach that promotes a better estimation of leishmaniasis burden and a deeper understanding of the spatial distribution of the key actors of the parasite life cycle (vectors, reservoirs and humans). We conducted a 14-year mixed retrospective and prospective study of leishmaniasis cases in an endemic area in southern Spain (Granada province), to estimate the human incidence and its association with the vector presence, cryptic leishmaniasis rates and canine leishmaniasis prevalence. We found an annual linear increase in the incidence that cannot be fully explained by active case surveillance and the improvement of PCR diagnostic techniques. 49.4% of cases were not reported to the surveillance system. Approximately half of the human cases correspond to the visceral form that occurred more frequently in men; cutaneous, mucosal and cryptic forms were also detected. Leishmaniasis is no longer a disease of young children, accounting for a quarter of immunocompetent patients and most infected people remained asymptomatic. Human and canine leishmaniasis, cryptic or symptomatic, are present in the whole province, where there is a medium/high risk of the presence of Phlebotomus perniciosus, the main vector. We found association between the incidence of human leishmaniasis and the presence of the vector, but not with the prevalence of canine leishmaniasis and cryptic human leishmaniasis. A potential hot spot was also found, where high leishmaniasis incidence may be associated to the involvement of host species other than dogs. |
| Databáze: | OpenAIRE |
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