Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
| Autor: | Demin Wang, Michael Brown, Dimitrios J. Stravopodis, Stephan Teglund, Jan M. van Deursen, Catriona McKay, James N. Ihle, Erin G. Schuetz, Sara Bodner, Gerard Grosveld |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_treatment
STAT5B General Biochemistry Genetics and Molecular Biology stat Mice STAT5B Gene Mammary Glands Animal STAT5 Transcription Factor medicine Animals Erythropoietin Transcription factor STAT5 Genetics biology Biochemistry Genetics and Molecular Biology(all) Ovary food and beverages JAK-STAT signaling pathway Milk Proteins Mice Mutant Strains Hematopoiesis Prolactin Cell biology DNA-Binding Proteins Cytokine Growth Hormone Trans-Activators biology.protein Body Constitution Cytokines Female Janus kinase Infertility Female Gene Deletion |
| Zdroj: | Cell. 93:841-850 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/s0092-8674(00)81444-0 |
| Popis: | A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The Jaks then phosphorylate cellular substrates, including members of the signal transducers and activators of transcription (Stat) family of transcription factors. Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines. To assess the role of the Stat5 proteins, mutant mice were derived that have the genes deleted individually or together. The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin. Conversely, the responses to a variety of cytokines that activate the Stat5 proteins, including erythropoietin, are largely unaffected. |
| Databáze: | OpenAIRE |
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