A Subpopulation of Olfactory Bulb GABAergic Interneurons Is Derived from Emx1- and Dlx5/6-Expressing Progenitors
| Autor: | Marc Ekker, Minoree Kohwi, Jason E. Long, Yuchio Yanagawa, Arturo Alvarez-Buylla, John L.R. Rubenstein, Kunihiko Obata, Magdalena A. Petryniak |
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| Rok vydání: | 2007 |
| Předmět: |
Telencephalon
Calbindins Ganglionic eminence Dopamine EMX1 Subventricular zone Mice Transgenic Biology Calbindin Article Mice S100 Calcium Binding Protein G Cell Movement Interneurons medicine Animals Brain Tissue Transplantation Cell Lineage Cells Cultured gamma-Aminobutyric Acid Homeodomain Proteins Stem Cells musculoskeletal neural and ocular physiology General Neuroscience Graft Survival fungi Neurogenesis Cell Differentiation Olfactory Bulb Olfactory bulb Mice Inbred C57BL medicine.anatomical_structure nervous system Calbindin 2 GABAergic Calretinin Neuroscience Transcription Factors |
| Zdroj: | Journal of Neuroscience. 27:6878-6891 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | The subventricular zone (SVZ) of the postnatal brain continuously generates olfactory bulb (OB) interneurons. We show that calretinin+, calbindin+, and dopaminergic (TH+) periglomerular OB interneurons correspond to distinct subtypes of GABAergic cells; all were produced in the postnatal mouse brain, but they matured and were eliminated at different rates. The embryonic lateral ganglionic eminence (LGE) is thought to be the site of origin of postnatal SVZ neural progenitors. Consistently, grafts of the embryonic LGE into the adult brain SVZ generated many OB interneurons, including TH+ and calbindin+ periglomerular interneurons. However, calretinin+ cells were not produced from these LGE grafts. Surprisingly, pallial and septal embryonic progenitors transplanted into the adult brain SVZ also resulted in the generation of OB interneurons, including calretinin+ cells. A subset of Dlx2+ OB interneurons was derived from cells expressing Emx1, a transcription factor largely restricted to the pallium during development. Emx1 lineage-derived cells contributed a substantial portion of GABAergic cells in the OB, including calretinin+ interneurons. This is in contrast to cortex, in which Emx1 lineage-derived cells do not differentiate into GABAergic neurons. Our results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneurons. |
| Databáze: | OpenAIRE |
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