Modeling the Dynamics of Human Liver Failure Post Liver Resection
| Autor: | Babita K. Verma, Rajanikanth Vadigepalli, Pushpavanam Subramaniam |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Metabolic load medicine.medical_specialty medicine.medical_treatment Bioengineering lcsh:Chemical technology Article Resection lcsh:Chemistry Remnant liver 03 medical and health sciences Liver disease 0302 clinical medicine virtual patient dynamic modeling Internal medicine medicine Chemical Engineering (miscellaneous) lcsh:TP1-1185 liver regeneration Human liver business.industry Process Chemistry and Technology liver failure Liver failure medicine.disease Liver regeneration 3. Good health cell death 030104 developmental biology lcsh:QD1-999 030220 oncology & carcinogenesis liver resection Cardiology Hepatectomy business |
| Zdroj: | Processes Volume 6 Issue 8 Processes, Vol 6, Iss 8, p 115 (2018) |
| ISSN: | 2227-9717 |
| DOI: | 10.3390/pr6080115 |
| Popis: | Liver resection is an important clinical intervention to treat liver disease. Following liver resection, patients exhibit a wide range of outcomes including normal recovery, suppressed recovery, or liver failure, depending on the regenerative capacity of the remnant liver. The objective of this work is to study the distinct patient outcomes post hepatectomy and determine the processes that are accountable for liver failure. Our model based approach shows that cell death is one of the important processes but not the sole controlling process responsible for liver failure. Additionally, our simulations showed wide variation in the timescale of liver failure that is consistent with the clinically observed timescales of post hepatectomy liver failure scenarios. Liver failure can take place either instantaneously or after a certain delay. We analyzed a virtual patient cohort and concluded that remnant liver fraction is a key regulator of the timescale of liver failure, with higher remnant liver fraction leading to longer time delay prior to failure. Our results suggest that, for a given remnant liver fraction, modulating a combination of cell death controlling parameters and metabolic load may help shift the clinical outcome away from post hepatectomy liver failure towards normal recovery. |
| Databáze: | OpenAIRE |
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