What evolution tells us about protein physics, and protein physics tells us about evolution
| Autor: | Ugo Bastolla, Julián Echave, Yves Dehouck |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Evolution Functional dynamics Otras Ciencias Biológicas Biophysics Biology Biophysical Phenomena Protein evolution Ciencias Biológicas Evolution Molecular 03 medical and health sciences Structural Biology Molecular evolution Molecular Biology Genetics Physics Protein Stability Protein Proteins Variety (cybernetics) Folding (chemistry) 030104 developmental biology Evolutionary biology Proteins metabolism Mutation (genetic algorithm) Mutation Epistasis CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Current opinion in structural biology. 42 |
| ISSN: | 1879-033X |
| Popis: | The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformations are increasingly recognized to play a major role, concerning, for example, aggregation, folding kinetics, or functional dynamics. Besides molecular requirements on fitness, the stability of native and alternative conformations is modulated by a variety of factors, including population size, selective pressure on the replicative system, which determines mutation rates and biases, and epistatic effects. We discuss some of the recent advances, open questions, and integrating views in protein evolution, in light of the many underlying trade-offs, correlations, and dichotomies. Fil: Bastolla, Ugo. Centro de Biologia Molecular “Severo Ochoa”; España Fil: Dehouck, Yves. Université Libre de Bruxelles. Machine Learning Group; Bélgica Fil: Echave, Julián. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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