Measurements of whole body retention of diphosphonate and other indices of bone metabolism in 125 normals: Dependency on age, sex and glomerular filtration
| Autor: | Grethe Finn Jensen, Nikolaj Bokg Mogensen, Lars Hiyldstrup, Peter McNair, Ib Transbøl |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system Clinical Biochemistry Renal function Bone and Bones Bone resorption Bone remodeling Excretion Hydroxyproline chemistry.chemical_compound Sex Factors Internal medicine medicine Humans Aged Diphosphonates Chemistry Age Factors General Medicine Middle Aged Alkaline Phosphatase Endocrinology Creatinine Alkaline phosphatase Female Analysis of variance Glomerular Filtration Rate |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 44:673-678 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365518409083629 |
| Popis: | Measurements of 24-h whole body retention of 99m-Tc-MDP (WBR) has been performed in 125 normal volunteers, together with determinations of serum alkaline phosphatase, urinary hydroxyproline excretion and creatinine clearance. WBR decreased slightly from the 3rd to the 4th decade, after which it increased gradually in the older age-groups. Serum alkaline phosphatase followed an identical pattern, while the urinary hydroxyproline excretion demonstrated a marked but temporary rise in the post-menopausal age-groups. Finally, the creatinine clearance decreased gradually in the older age groups. Analysis of variance demonstrated that WBR varied independently with serum alkaline phosphatase and creatinine clearance, while no relationship between WBR and the hydroxyproline excretion was found. It seems likely that the increasing retention of diphosphonate in elderly persons reflects rising osteoblastic activity as well as decreasing glomerular filtration. |
| Databáze: | OpenAIRE |
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