Disseminated intravascular coagulation does not play a major role in the pathogenesis of classical swine fever
| Autor: | Sandra Blome, Volker Moennig, Götz Nowak, Alexandra Meindl-Böhmer |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Swine
Sus scrofa Hirudin Disease Microbiology Virus Classical Swine Fever Pathogenesis Leukocyte Count Random Allocation medicine Coagulation testing Animals Disseminated intravascular coagulation General Veterinary biology Platelet Count business.industry Fibrinogen General Medicine Disseminated Intravascular Coagulation Hirudins medicine.disease biology.organism_classification Thrombocytopenia Classical Swine Fever Virus Direct thrombin inhibitor Classical swine fever Immunology Partial Thromboplastin Time business medicine.drug |
| Zdroj: | Veterinary Microbiology. 162:360-368 |
| ISSN: | 0378-1135 |
| DOI: | 10.1016/j.vetmic.2012.10.008 |
| Popis: | Classical swine fever (CSF) is a multi-systemic disease that can be accompanied by severe haemorrhagic lesions. The underlying pathogenetic mechanisms are still far from being understood, though disseminated intravascular coagulation (DIC) was discussed as a major factor. In the presented study, the direct thrombin inhibitor hirudin was used in an attempt to elucidate the role of the coagulation system in the pathogenesis of CSF-induced haemorrhagic lesions. Two groups of piglets ( n = 5) were infected with highly virulent CSF virus (CSFV) strain CSF0634. One group underwent daily treatment with hirudin, the other served as untreated challenge infection control. Assessment of clinical signs using a clinical score system, coagulation tests, and blood counts were performed daily. Both groups developed acute-lethal CSF with haemorrhagic lesions. Although changes in the coagulation system were seen in the late stages of CSFV infection, our results strongly suggest that DIC does not present the crucial event in the pathogenesis of haemorrhagic lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect