Disentangling chromatin architecture to gain insights into the etiology of brain disorders
Autor: | Janine M. Lamonica, Zhaolan Zhou |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0303 health sciences
Cell type Brain Diseases biology medicine.disease Article Chromatin Epigenesis Genetic Histones 03 medical and health sciences 0302 clinical medicine Histone Genetics biology.protein medicine Autism Chromosomes Human Humans Architecture Trinucleotide repeat expansion Neuroscience 030217 neurology & neurosurgery 030304 developmental biology Developmental Biology |
Zdroj: | Curr Opin Genet Dev |
Popis: | Chromatin organization, together with DNA and histone modifications, is directly linked to the spatiotemporal control of gene expression that specifies and maintains cell type-specific functions. This is particularly important in the brain where hundreds of cell types with distinct functions reside. Recent advances in molecular and computational technologies have enabled the query of chromatin architecture at unprecedented resolution and detail. Here, we review recent studies on the emerging importance of chromatin architecture in the pathogenesis of brain disorders, with emphasis on schizophrenia, autism spectrum disorders (ASD), and unstable repeat expansion disorders. These studies provide molecular insights into how these brain disorders arise at the level of chromatin architecture and implicate new therapeutic directions. |
Databáze: | OpenAIRE |
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