Neoplasms of the Forestomach in Mice Ingesting Dihydrosafrole
| Autor: | Melvin D. Reuber |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Male mice Mice Inbred Strains Dioxoles Gastroenterology Dihydrosafrole Mice chemistry.chemical_compound Stomach Neoplasms Oral administration Safrole Internal medicine medicine Animals Hyperplasia business.industry Stomach Liver Neoplasms Neoplasms Experimental medicine.disease stomatognathic diseases Endocrinology medicine.anatomical_structure chemistry Isosafrole business |
| Zdroj: | Digestion. 19:42-47 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000198320 |
| Popis: | The maximal tolerated doses of dihydrosafrole, safrole, and isosafrole were given by continuous oral administration, starting at the age of 7 days, to both sexes of two hybrid strains of mice – (C57BL/6 X C3HAnf)F 1 and (C57BL/6 X AKR)F 1 . Hyperplasia and carcinomas of the forestomach were significantly increased in female mice of both strains and in male mice of the latter strain ingesting dihydrosafrole. By contrast, neoplasms of the forestomach were not increased in mice receiving safrole or isosafrole. Mice with neoplasms of the stomach generally did not have neoplasms of the liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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