Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children
| Autor: | Thomas Reinehr, Franca F. Kirchberg, Berthold Koletzko, Nina Lass, Ulrike Harder, Christian Hellmuth, Wolfgang Peissner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Adolescent Article Subject Endocrinology Diabetes and Metabolism Metabolite 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin resistance Weight loss Internal medicine medicine Humans Metabolomics Obesity Tyrosine Child Life Style Glucose tolerance test lcsh:RC648-665 medicine.diagnostic_test business.industry Metabolism Glucose Tolerance Test medicine.disease 030104 developmental biology Metabolomic profiling chemistry Female medicine.symptom Insulin Resistance business Amino Acids Branched-Chain Research Article |
| Zdroj: | Journal of Diabetes Research, Vol 2016 (2016) Journal of Diabetes Research |
| ISSN: | 2314-6753 2314-6745 |
| Popis: | In obese children, hyperinsulinaemia induces adverse metabolic consequences related to the risk of cardiovascular and other disorders. Branched-chain amino acids (BCAA) and acylcarnitines (Carn), involved in amino acid (AA) degradation, were linked to obesity-associated insulin resistance, but these associations yet have not been studied longitudinally in obese children. We studied 80 obese children before and after a one-year lifestyle intervention programme inducing substantial weight loss >0.5 BMI standard deviation scores in 40 children and no weight loss in another 40 children. At baseline and after the 1-year intervention, we assessed insulin resistance (HOMA index), fasting glucose, HbA1c, 2 h glucose in an oral glucose tolerance test, AA, and Carn. BMI adjusted metabolite levels were associated with clinical markers at baseline and after intervention, and changes with the intervention period were evaluated. Only tyrosine was significantly associated with HOMA (p<0.05) at baseline and end and with change during the intervention (p<0.05). In contrast, ratios depicting BCAA metabolism were negatively associated with HOMA at baseline (p<0.05), but not in the longitudinal profiling. Stratified analysis revealed that the children with substantial weight loss drove this association. We conclude that tyrosine alterations in association with insulin resistance precede alteration in BCAA metabolism. This trial is registered with ClinicalTrials.gov IdentifierNCT00435734. |
| Databáze: | OpenAIRE |
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