Near-Infrared-Emitting Hemicyanines and Their Photodynamic Killing of Cancer Cells
| Autor: | Gavin P. Birch, Mark Bradley, Mithun Santra, Matthew Owens |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
hemicyanines
Singlet Oxygen Chemistry near-infrared emitting Biochemistry (medical) Near-infrared spectroscopy Biomedical Engineering General Chemistry Photochemistry Biomaterials photodynamic therapy Photochemotherapy Neoplasms Cancer cell fluorescence Coloring Agents Reactive Oxygen Species heavy atom |
| Zdroj: | Santra, M, Owens, M, Birch, G & Bradley, M 2021, ' Near-Infrared-Emitting Hemicyanines and Their Photodynamic Killing of Cancer Cells ', ACS Applied Biomaterials . https://doi.org/10.1021/acsabm.1c00996 |
| ISSN: | 2576-6422 |
| DOI: | 10.1021/acsabm.1c00996 |
| Popis: | A series of hemicyanine dyes was synthesized starting from the vinyl chloride-based cyanine dye IR-780. The dyes absorbed and emitted in the near-infrared region, while heavy atom (bromo and iodo) substitution promoted the generation of both singlet oxygen (1O2) as well as a range of other reactive oxygen-based species (ROS) upon irradiation at wavelengths greater than 610 nm. One hemicyanine dye displayed an outstanding singlet oxygen quantum efficiency (φΔ = 0.8) and was successfully applied in in vitro studies to mimic photodynamic therapy application. |
| Databáze: | OpenAIRE |
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