Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila
| Autor: | Pierre Léopold, Ditte S. Andersen, Laura Boulan, Emilie Boone, Julien Colombani |
|---|---|
| Přispěvatelé: | Génétique et Biologie du Développement, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), RUIZ, Caroline, HAL-SU, Gestionnaire |
| Jazyk: | angličtina |
| Předmět: |
Male
MESH: Signal Transduction coordination [SDV]Life Sciences [q-bio] Small ribosomal subunit Minute organ growth 0302 clinical medicine MESH: Gene Expression Regulation Developmental Drosophila Proteins MESH: Animals Dilp8 0303 health sciences Intracellular Signaling Peptides and Proteins [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis Gene Expression Regulation Developmental MESH: Ribosomal Proteins Cell biology [SDV] Life Sciences [q-bio] DNA-Binding Proteins Imaginal disc Drosophila melanogaster Imaginal Discs MESH: Imaginal Discs Intercellular Signaling Peptides and Proteins Female Drosophila Signal Transduction Ribosomal Proteins MAP Kinase Signaling System MESH: Drosophila Proteins RpS12 Protein Serine-Threonine Kinases Biology General Biochemistry Genetics and Molecular Biology MESH: Protein-Serine-Threonine Kinases MESH: Drosophila melanogaster 03 medical and health sciences MESH: Intracellular Signaling Peptides and Proteins Animals Drosophila (subgenus) MESH: Intercellular Signaling Peptides and Proteins Molecular Biology Transcription factor 030304 developmental biology Xrp1 MESH: MAP Kinase Signaling System Cell Biology biology.organism_classification MESH: Male [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis MESH: Female 030217 neurology & neurosurgery MESH: DNA-Binding Proteins Developmental Biology |
| Zdroj: | Developmental Cell Developmental Cell, Elsevier, 2019, 49 (5), pp.811-818.e4. ⟨10.1016/j.devcel.2019.03.016⟩ Developmental Cell, 2019, 49 (5), pp.811-818.e4. ⟨10.1016/j.devcel.2019.03.016⟩ |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2019.03.016 |
| Popis: | How organs scale with other body parts is not mechanistically understood. We have addressed this question using the Drosophila imaginal disc model. When growth of one disc domain is perturbed, other parts of the disc and other discs slow down their growth, maintaining proper inter-disc and intra-disc proportions. We show here that the relaxin-like Dilp8 is required for this inter-organ coordination. Our work also reveals that the stress-response transcription factor Xrp1 plays a key role upstream of dilp8 in linking organ growth status with non-autonomous/systemic growth response. In addition, we show that the small ribosomal subunit protein RpS12 is required to trigger Xrp1-dependent non-autonomous response. Our work demonstrates that RpS12, Xrp1 and Dilp8 constitute a new, independent regulatory module that ensures intra- and inter-organ growth coordination during development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|