Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
| Autor: | Barbara Zanchet, Bianca de Oliveira Alves, Gabriela Adriany Lisboa Zilli, Walter Antônio Roman Junior, Sinval Adalberto Rodrigues Junior, Amanda P. Schönell, Régis Carlos Benvenutti, Ana Lúcia Tasca Gois Ruiz, Junir Lutinski, Kriptsan A.P. Diel, Daniela Miorando, Cristian Alex Dalla Vechia, Thais Petrochelli Banzato, Max Vidal Gutiérrez, Jackeline Ernetti, Wagner Vilegas, Denise B. Gomes, Gelvani Locateli, Patrícia Zanotelli Serpa |
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| Přispěvatelé: | Community Univ Reg Chapeco, Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Multidisciplinary Traditional medicine biology Chemistry Cell Ethyl acetate Fatty acid biology.organism_classification In vitro antitumor agents Urera baccifera Ovarian tumor chemistry.chemical_compound medicine.anatomical_structure Cell culture chemical analysis medicine Medicinal plants TP248.13-248.65 Biotechnology medicinal plants |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Brazilian Archives of Biology and Technology v.62 2019 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR Brazilian Archives of Biology and Technology, Volume: 62, Article number: e19180531, Published: 24 OCT 2019 |
| ISSN: | 1516-8913 |
| Popis: | Made available in DSpace on 2020-12-10T19:40:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01. Added 1 bitstream(s) on 2021-07-15T15:06:44Z : No. of bitstreams: 1 S1516-89132019000100412.pdf: 585705 bytes, checksum: 3a2d47e9df2f97ad2af651f38c9af498 (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Unochapeco Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigao. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The hydroalcoholic extract was inactive while dichloromethane extract showed moderate cytostatic activity against ovarian carcinoma cell line (OVCAR-3, GI(50) = 1.5 mu g/mL). More, the ethyl acetate and n-butanol fractions did not show important activity against tumour cell while the dichloromethane and hexane fractions showed moderate cytostatic activity against ovarian tumor cell line (OVCAR-3, GI(50) = 12.7 and 9.4 mu g/mL, respectively). Finally, the chemical profile evaluated by mass spectrometry (ESI-IT-MSn) allowed the detection of flavonoids in the HEU and hydroxylated fatty acid in DEU that can explain partially the biological effects observed. This is the first report of the antiproliferative effects of U. baccifera, and DEU has shown potential as a promising source of bioactive compounds. Community Univ Reg Chapeco, Hlth Sci Postgrad Program, Chapeco, SC, Brazil Community Univ Reg Chapeco, Lab Pharmacognosy, Chapeco, SC, Brazil Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP, Brazil State Univ Sao Paulo Juilo de Mesquita Filho, Inst Biosci, Sao Vicente, SP, Brazil State Univ Sao Paulo Juilo de Mesquita Filho, Inst Biosci, Sao Vicente, SP, Brazil |
| Databáze: | OpenAIRE |
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