Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study
| Autor: | Yangjia Lu, Shaoyang Cui, Yong Huang, Guifeng Zhang, Xiaowen Cai, Shanshan Qu, Genevieve Z. Steiner, Zheng Zhong, Junqi Chen, Xinsheng Lai, Chunzhi Tang, Baoci Shan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty animal structures positron emission tomography Infralimbic cortex multi-target regulation mechanism Zusanli lcsh:RC346-429 compensation 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Cortex (anatomy) medicine Acupuncture long-term treatment rat nerve regeneration lcsh:Neurology. Diseases of the nervous system Dry needling medicine.diagnostic_test business.industry Neurodegeneration neurodegeneration Zusanli (ST36) Alzheimer's disease medicine.disease acupuncture Alzheimer′s disease targeting effect neural regeneration Pons 030104 developmental biology medicine.anatomical_structure Positron emission tomography business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Neural Regeneration Research Neural Regeneration Research, Vol 12, Iss 7, Pp 1159-1165 (2017) |
| ISSN: | 1673-5374 |
| Popis: | The acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm lateral to ST36) in a rat Alzheimer's disease model, for 30 minutes, once per day, for 30 days. The rats underwent 18F-fluorodeoxyglucose positron emission tomography scanning. Positron emission tomography images were processed with SPM2. The brain areas activated after needling at ST36 included the left hippocampus, the left orbital cortex, the left infralimbic cortex, the left olfactory cortex, the left cerebellum and the left pons. In the sham-point group, the activated regions were similar to those in the ST36 group. However, the ST36 group showed greater activation in the cerebellum and pons than the sham-point group. These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease. |
| Databáze: | OpenAIRE |
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