The impact of Candida spp airway colonization on clinical outcomes in patients with ventilator-associated pneumonia: A systematic review and meta-analysis
| Autor: | Mingjing Yu, Zongan Liang, Yuehong Hu, Dong Huang, Min Qi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Epidemiology medicine.medical_treatment Cochrane Library law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine Humans Colonization 030212 general & internal medicine Candida Retrospective Studies Mechanical ventilation 0303 health sciences 030306 microbiology business.industry Health Policy Public Health Environmental and Occupational Health Ventilator-associated pneumonia Pneumonia Ventilator-Associated medicine.disease Respiration Artificial Intensive care unit Intensive Care Units Observational Studies as Topic Pneumonia Infectious Diseases Relative risk Meta-analysis business |
| Zdroj: | American Journal of Infection Control. 48:695-701 |
| ISSN: | 0196-6553 |
| DOI: | 10.1016/j.ajic.2019.11.002 |
| Popis: | Background Previous studies have drawn different conclusions about the impact of Candida airway colonization on clinical outcomes in patients with ventilator-associated pneumonia (VAP). Methods We searched PubMed, the Cochrane Library, Embase (via OVID), and Web of Science database. We included both retrospective and prospective observational studies. The mean difference (MD) or risk ratio (RR) with 95% confidence intervals (CI) were applied to assess the association between Candida colonization and clinical outcomes. Results A total of 8 studies with 1,661 patients were pooled in our final studies. Compared with patients with VAP without Candida colonization, patients with Candida colonization had significantly longer durations of mechanical ventilation (MD, 1.93; 95% CI, 0.53-3.33). The intensive care unit (ICU) length of stay seems to be longer among Candida colonized patients than noncolonized patients, although the results were not so significant (MD, 1.15; 95% CI, –1.04 to 3.34). Patients with colonization had higher 28-day mortality and ICU mortality than those without colonization (28-day mortality: RR, 1.64; 95% CI, 1.27-2.12; ICU mortality: RR, 1.57; 95% CI, 1.26-1.94). Conclusions The presence of Candida spp airway colonization is associated with longer durations of mechanical ventilation, higher 28-day mortality, higher ICU mortality, and probably longer ICU length of stay compared with the absence of colonization in patients with VAP. |
| Databáze: | OpenAIRE |
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