Synthesis and antiproliferative activity of podocarpane and totarane derivatives

Autor:	Rachid Chahboun, Enrique Alvarez-Manzaneda, Soumicha Mahdjour, Fernando Rodríguez-Serrano, Juan J. Guardia, Nuria Mut-Salud, Jose Manuel Garrido, Isabel Blancas López-Barajas
Rok vydání:	2018
Předmět:	0301 basic medicine Cell Survival Stereochemistry Antineoplastic Agents Apoptosis 01 natural sciences Labdane 03 medical and health sciences chemistry.chemical_compound Cell Line Tumor Neoplasms Drug Discovery Humans IC50 Gaultheria Cell Proliferation Pharmacology Catechol biology 010405 organic chemistry Organic Chemistry General Medicine biology.organism_classification Terpenoid 0104 chemical sciences 030104 developmental biology chemistry Cell culture Abietanes Diterpenes Drug Screening Assays Antitumor Antiproliferative effect
Zdroj:	European Journal of Medicinal Chemistry. 158:863-873
ISSN:	0223-5234
Popis:	The synthesis of podocarpanes, including 12,19-dihydroxy-13-acetyl-8,11,13-podocarpatriene (23), isolated from Gaultheria yunnanensis and not previously synthesized, and totarane-type terpenoids, starting from the natural labdane trans-communic acid (15), is described. Their antiproliferative activities against MCF-7, T-84 and A-549 human tumoural cell lines are studied. An antiproliferative effect was induced by compounds 23, 27 and 28, with IC50
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de65a09a342b09a365812f7c8c77884 https://doi.org/10.1016/j.ejmech.2018.09.051 Zobrazit plný text záznamu Full Text from ScienceDirect