Opportunities for Translational Epidemiology: The Important Role of Observational Studies to Advance Precision Oncology
| Autor: | Andrew N. Freedman, Geoff Liu, Muin J. Khoury, Michael Marrone, Richard L. Schilsky |
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| Rok vydání: | 2015 |
| Předmět: |
Epidemiology
business.industry Conceptual model (computer science) Precision medicine Bioinformatics Data science Article Translational Research Biomedical Clinical trial Observational Studies as Topic Oncology Conceptual framework Multidisciplinary approach Neoplasms Humans Medicine The Conceptual Framework Observational study Epidemiologic Methods business |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 24:484-489 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-14-1086 |
| Popis: | Within current oncology practice, several genomic applications are being used to inform treatment decisions with molecularly targeted therapies in breast, lung, colorectal, melanoma, and other cancers. This commentary introduces a conceptual framework connecting the full spectrum of biomedical research disciplines, including fundamental laboratory research, clinical trials, and observational studies in the translation of genomic applications into clinical practice. The conceptual framework illustrates the contribution that well-designed observational epidemiologic studies provide to the successful translation of these applications, and characterizes the role observational epidemiology plays in driving the dynamic and iterative bench-to-bedside, and bedside-to-bench translation continuum. We also discuss how the principles of this conceptual model, emphasizing integration of multidisciplinary research, can be applied to the evolving paradigm in “precision oncology” focusing on multiplex tumor sequencing, and we identify opportunities for observational studies to contribute to the successful and efficient translation of this paradigm.Cancer Epidemiol Biomarkers Prev; 24(3); 484–9. ©2015 AACR. |
| Databáze: | OpenAIRE |
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