Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck
| Autor: | Abhay S. Gokhale, Jarrod Faucher, Lori J. Wirth, Melissa Hallar, Marshall R. Posner, Robert I. Haddad, Lisa A. Cavacini, Linda Weeks |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Cancer Research medicine.medical_specialty medicine.medical_treatment Pilot Projects chemistry.chemical_compound Growth factor receptor Epidermal growth factor Internal medicine Biomarkers Tumor Medicine Humans Interleukin 8 Epidermal growth factor receptor Aged Neoplasm Staging biology business.industry Head and neck cancer Interleukin-8 Middle Aged medicine.disease Neoplasm Proteins Vascular endothelial growth factor ErbB Receptors stomatognathic diseases Endocrinology Cytokine Oncology chemistry Head and Neck Neoplasms Cancer research biology.protein Carcinoma Squamous Cell Biomarker (medicine) Female Oral Surgery Neoplasm Recurrence Local business |
| Zdroj: | Oral oncology. 41(1) |
| ISSN: | 1368-8375 |
| Popis: | Squamous cell cancer of the head and neck (SCCHN) is associated with production of pro-inflammatory and pro-angiogenic cytokines. We hypothesized that cytokine serum levels will correlate with tumor volume and aggressiveness. We investigated interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) in SCCHN. The patient population consisted of normal and irradiated controls: patients with newly diagnosed SCCHN, and patients with recurrent or metastatic disease. Pretreatment sera were studied by ELISA. Serum IL-8 levels, as opposed to VEGF or EGFR, were consistently elevated in patients with recurrent or metastatic disease. The differences in mean serum IL-8, compared to controls, were significant (p=0.02). Serum levels of IL-8 are consistently elevated in patients with recurrent or metastatic SCCHN and elevated levels may correlate with advanced or aggressive disease. Further, more intensive, study of IL-8 as a biomarker in SCCHN is warranted. |
| Databáze: | OpenAIRE |
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