Salivary melatonin in oral squamous cell carcinoma patients

Autor: Jasna Lovrić, Ivan Zajc, Ivana Karmelić, Marko Rožman, Ksenija Baždarić, Darko Macan, Davor Brajdić, Ivan Salarić, Igor Čvrljević
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Oncology
Male
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences
Pittsburgh Sleep Quality Index
0302 clinical medicine
Medicine
Stage (cooking)
salivary melatonin
oral cancer
circadian rhythm
sleep quality
Cancer
Melatonin
0303 health sciences
Multidisciplinary
Circadian rhythm
Oral cancer
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti
Sleep quality
Middle Aged
3. Good health
Poor sleep
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Female
Mouth Neoplasms
medicine.drug
medicine.medical_specialty
BIOMEDICINA I ZDRAVSTVO. Dentalna medicina
Science
Article
03 medical and health sciences
Internal medicine
Biomarkers
Tumor
Humans
Basal cell
BIOMEDICINE AND HEALTHCARE. Dental Medicine
Saliva
030304 developmental biology
Dental Medicine
Salivary
business.industry
stomatognathic diseases
ROC Curve
Case-Control Studies
business
Sleep
Salivary melatonin
Biomarkers
Zdroj: Scientific Reports
Scientific reports
Volume 11
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
ISSN: 2045-2322
Popis: Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and anti-inflammatory properties. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. The purpose of this study is to determine salivary melatonin (MLT) levels in oral squamous cell carcinoma (OSCC) patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. Unstimulated (UWS) and stimulated (SWS) whole saliva was sampled from patients with T1N0M0 and T2N0M0 OSCC (N = 34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (P = 0.0001). ROC analysis was found to be significant (P
Databáze: OpenAIRE
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