Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives
| Autor: | Nathaniel Ginder, Alison C. Burggren, Edythe D. London, Anaheed Shirazi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
cognition
Autism Spectrum Disorder medicine.medical_treatment Medicine (miscellaneous) Epilepsies Myoclonic Epilepsies Infantile Spasms cannabidiol tetrahydrocannabinol 0302 clinical medicine Cognition morphology Cannabidiol Psychology Dronabinol Legalization biology Age Factors Substance Abuse Brain Organ Size Psychiatry and Mental health Clinical Psychology Public Health and Health Services Spasms Infantile medicine.drug medicine.medical_specialty brain Medical Marijuana Article 03 medical and health sciences medicine Humans Psychiatry Tetrahydrocannabinol Recreation Cannabis Illicit Substance Lennox Gastaut Syndrome Brain morphometry Infant endocannabinoid biology.organism_classification 030227 psychiatry Attention Deficit Disorder with Hyperactivity Cannabinoid Myoclonic 030217 neurology & neurosurgery Endocannabinoids |
| Zdroj: | The American journal of drug and alcohol abuse, vol 45, iss 6 |
| Popis: | BACKGROUND: Cannabis is the most widely used illicit substance worldwide, and legalization for recreational and medical purposes has substantially increased its availability and use in the United States. OBJECTIVES: Decades of research have suggested that recreational cannabis use confers risk for cognitive impairment across various domains, and structural and functional differences in the brain have been linked to early and heavy cannabis use. METHODS: With substantial evidence for the role of the endocannabinoid system in neural development and understanding that brain development continues into early adulthood, the rising use of cannabis in adolescents and young adults raises major concerns. Yet some formulations of cannabinoid compounds are FDA-approved for medical uses, including applications in children. RESULTS: Potential effects on the trajectory of brain morphology and cognition, therefore, should be considered. The goal of this review is to update and consolidate relevant findings in order to inform attitudes and public policy regarding the recreational and medical use of cannabis and cannabinoid compounds. CONCLUSIONS: The findings point to considerations for age limits and guidelines for use. |
| Databáze: | OpenAIRE |
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