STEROIDAL INDUCTION OF THE PREMATURE GROWTH SPURT IN PREPUBERTAL BOYS FOR EXCESSIVE HEIGHT

Autor:	Graham Wh, Whitelaw Mj, Foster Tn
Rok vydání:	1965
Předmět:	Male medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Puberty Precocious General Medicine Growth spurt Body Height Endocrinology Internal medicine medicine Humans Testosterone Child business Epiphyses
Zdroj:	Acta Endocrinologica. 50:317-320
ISSN:	1479-683X 0804-4643
DOI:	10.1530/acta.0.0500317
Popis:	Five prepubertal males ranging in age from 8–11 and whose estimated heights were all over 195 cm were treated by the induction of a premature puberty with testosterone oenanthate 200 mg twice monthly for 9 months in 4 and 5 months in one. During the first 8 months their linear growth increase ranged between 13.7 and 6.4 cm. There was also a corresponding sharp increase in weight of as much as 17.24 kg in one patient. The bone age advanced 51 months in a 9 year old boy, while in the eldest, age 11, the advance was only 24 months. There is a definite lag in the radiological evidence of epiphyseal acceleration for the first 3–4 months of anabolic therapy. After discontinuation of therapy, evidence of acceleration may persist for a like period. The final height of 4 boys is far under the estimated height on the Bayley table, the fifth is still not determined. Genital development and secondary sex characteristics were noted after the first month of therapy. The growth spurt induced by testosterone oenanthate duplicated that normally seen in the 12–14 year old boy. There is no psychic disturbance by the induction of puberty.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd6034b4c9dcb399b83e7eb1c26ddba https://doi.org/10.1530/acta.0.0500317 Zobrazit plný text záznamu