Stabilization of clinical samples collected for quantitative bioanalysis--a reflection from the European Bioanalysis Forum
| Autor: | Richard Abbott, Martijn Hilhorst, Katja Heinig, Elke Zwanziger, Peter van Amsterdam |
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| Rok vydání: | 2015 |
| Předmět: |
Bioanalysis
Analyte Light Clinical Biochemistry Nanotechnology Urinalysis Antioxidants Analytical Chemistry Specimen Handling Clinical study Stabilization methods Humans General Pharmacology Toxicology and Pharmaceutics Nonspecific binding Chemistry Hydrolysis Temperature General Medicine Hydrogen-Ion Concentration Method development Europe Medical Laboratory Technology Risk analysis (engineering) Personnel safety Sample collection Adsorption Blood Chemical Analysis |
| Zdroj: | Bioanalysis. 7(3) |
| ISSN: | 1757-6199 |
| Popis: | In bioanalysis of small molecules, the analyte concentration in the measured samples should reflect the concentration during sample collection. Precautions may be needed to prevent over- or under-estimation of the obtained result. This might require the addition of stabilizers to prevent degradation or nonspecific binding. For unstable drugs, it is essential to know how analytes can be stabilized before the start of the clinical study. Although the stabilization methods are well documented, the impact of the stabilization on the clinical workflow is not properly addressed. Already during method development, the clinical implications in terms of personnel safety, ease of use, training possibilities and staff capacity should be taken into account, and validation of the bioanalytical method should reflect collection procedures. |
| Databáze: | OpenAIRE |
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