Site of initial excitation and current threshold as a function of electrode radius in heart muscle
| Autor: | Jan J. Denier van der Gon, Fred W. Lindemans, Ariaen N. E. Zimmerman, R.M. Heethaar |
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| Rok vydání: | 1975 |
| Předmět: |
Materials science
Physiology 9 mm caliber Current threshold Depolarization Heart Radius Anatomy Function (mathematics) Papillary Muscles Atrial Function Electric Stimulation Dogs Physiology (medical) Electrode Animals Ventricular Function Current (fluid) Atomic physics Electronics Cardiology and Cardiovascular Medicine Electrodes Excitation Platinum |
| Zdroj: | Cardiovascular research. 9(1) |
| ISSN: | 0008-6363 |
| Popis: | End-diastolic current thresholds have been measured in 13 open chested dogs as a function of electrode radius by stimulating the left ventricle with epicardial disc electrodes ranging in a radius from 0-3 mm to 9 mm. Thresholds for cathodal rectangular short stimuli as well as specifically for cathodal make stimulation, proved to be proportional to the electrode radius to the power 1-5. This relationship between radius and threshold can be explained theoretically, assuming that electrical stimulation results in a propagated depolarization front if a critical current density is reached somewhere in the myocardium. The current distribution measured over the electrode and the site of initial depolarization in the tissue are in accordance with this theoretical explanation. |
| Databáze: | OpenAIRE |
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