Contact transcleral photodynamic cyclo-suppression in human eyes: a feasibility study
| Autor: | Vania Vitanova, Efstathios T. Detorakis, Spyridon K Charisis, Miltiadis K. Tsilimbaris, G Kounis, Vassilios Panteleontidis |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure Porphyrins genetic structures Glaucoma Irradiation time Ciliary body Refractory Ophthalmology Humans Medicine Prospective Studies Intraocular Pressure Aged Aged 80 and over Photosensitizing Agents business.industry Lasers Ciliary Body Verteporfin General Medicine Middle Aged medicine.disease eye diseases Surgery Glaucoma Neovascular medicine.anatomical_structure Photochemotherapy Feasibility Studies Female Laser Therapy sense organs business Sclerocorneal Limbus Bolus (radiation therapy) Sclera Follow-Up Studies |
| Zdroj: | Canadian Journal of Ophthalmology. 46:196-198 |
| ISSN: | 0008-4182 |
| DOI: | 10.3129/i10-109 |
| Popis: | To evaluate the safety and efficacy of contact transcleral ciliary body photodynamic treatment (CB-PDT) with verteporfin in human eyes.Prospective interventional case series.Five glaucomatous blind eyes of 5 patients.Verteporfin (6 mg/m(2)) was infused in bolus and then the ciliary body was irradiated transclerally with a fibre optic device. Twelve spots were placed 360° and 0.5 mm behind the sclerocorneal limbus. Laser power was 80 mW and irradiation time was 3 minutes.The average intraocular pressure reduction was 30% after the first month and remained below pre-treatment levels throughout a 3-month follow-up. No serious adverse events were reported.CB-PDT for refractory glaucoma was safe and efficient in human eyes; larger studies are required to evaluate its possible clinical role. |
| Databáze: | OpenAIRE |
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