Role of Matrix Metalloproteinases in Angiogenesis and Cancer
| Autor: | María Elizbeth Alvarez-Sánchez, Enrique Becerril-Villanueva, Julio Lara-Riegos, Victor Arana-Argáez, Mario Alberto Ramírez-Camacho, Rodrigo Arreola, Saray Quintero-Fabián, Julio César Torres-Romero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Angiogenesis Review Matrix (biology) Matrix metalloproteinase lcsh:RC254-282 metalloproteinases Metastasis Neovascularization Extracellular matrix 03 medical and health sciences 0302 clinical medicine medicine Basement membrane MT-MMP MMP Chemistry angiogenesis and cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell biology Endothelial stem cell immune system 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis medicine.symptom |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 9 (2019) |
| ISSN: | 2234-943X |
| Popis: | During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metalloproteinases (MMPs) participate in the disruption, tumor neovascularization, and subsequent metastasis while tissue inhibitors of metalloproteinases (TIMPs) downregulate the activity of these MMPs. Then, the angiogenic response can be directly or indirectly mediated by MMPs through the modulation of the balance between pro- and anti-angiogenic factors. This review analyzes recent knowledge on MMPs and their participation in angiogenesis. |
| Databáze: | OpenAIRE |
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